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Interaction of IRS2 with PLK1 protects cells from mitotic stress
Ji-Sun Lee*, Quyen Thu Bui, Minjeong Jo, Jennifer S.Morgan, Isha Nasa, Arminja N. Kettenbach, Leslie M. Shaw*
Cell Death and Disease, 2026-Apr
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Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.
Claire E Tocheny, Julianna E Buchwald, Christopher D Dahlke, Hassan H Fakih, Jennifer S Morgan, Ashley Summers, Christi A Wisniewski, Samuel O Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M Mercurio, Aanastasia Khvorova, Leslie M Shaw.
Molecular Therapy, 2026-Jan
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Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function.
Minjeong Jo, Ji-Sun Lee, Claire E. Tocheny, Michael W. Lero, Quyen Thu Bui, Jennifer S. Morgan, and Leslie M. Shaw.
Journal of Biological Chemistry, 2024-Sep
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The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC.
Ji-Sun Lee, Michael W. Lero, Jose Mercado-Matos, Sha Zhu, Minjeong Jo, Claire E. Tocheny, Jennifer S. Morgan and Leslie M. Shaw
Cell Reports, 2022-Dec
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The insulin-like growth factor signaling pathway in breast cancer: an elusive therapeutic target
Ji-Sun Lee*, Claire E. Tocheny* and Leslie M. Shaw.
Life, 2022-Nov
