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TANK-binding kinase 1 protects against MASH progression via mitochondrial quality control
Sung-Min An, Jun Hee Jang, Jin Hyun Sung, Ji Won Myung, Yong Geun Jeon, Won Taek Lee, Jin Won Jeon, Kyung Min Yim, Jae-Ho Lee, Bichen Zhang , Jong Bae Seo, Seung Soon Im , Jae Bum Kim, Alan R Saltiel, Jin Young Huh
Experimental & Molecular Medicine, 2026.3.13
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Progranulin Deficiency Improves Metabolic Stress Yet Falls Short of Sodium-Glucose Cotransporter-2 Inhibition in Autophagy-Linked Renal Protection
Seung-Soon Im
Endocrinology and Metabolism, 2026.2.
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Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation
Giang Nguyen #, Ji Hee Yu #, Phuc Thi Minh Pham, Thuy Linh Lai, So Young Park, Ki Woo Kim, Seung-Soon Im, Jeana Hong, Yong-Ho Lee, Jae-Ho Lee, Seon Mee Kang, Dae-Hee Choi, Eun-Hee Cho
DIABETES & METABOLISM JOURNAL, 2026.3
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Myeloid-Specific STAT3 Deletion Aggravates Liver Fibrosis in Mice Fed a Methionine- and Choline-Deficient Diet via Upregulation of Hepatocyte-Derived Lipocalin-2
Kyung Eun Kim, Hyun Joo Shin, Hyeong Seok An, Eun Ae Jeong, Yundong Sun, Jiwon Oh, Jiwoo Park, Jaewoong Lee, Seung-Soon Im, Gu Seob Roh
Cells, 2025.9.29
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A novel yeast-derived aldehyde-reducingcompound MF001 protects againstalcohol-induced liver damage
Eun-Ho Lee, Min-Hee Seo, Soo-Young Park, Sulagna Mukherjee, Jae-Ho Lee,Sora Kang, Ji-Yu Lee, Namgyu Lee, Hung Taeck Kwon, Seung-Soon Im
Plos one, 2025.7.10
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Liver Receptor Homolog-1 Deficiency Impairs Alcohol-Associated Liver Disease Owing to Decrease of Aldehyde Dehydrogenase 1 Family Member B1 Gene Expression
Min-Hee Seo, Jae-Ho Lee, Eun-Ho Lee, Sulagna Mukherjee, Soo-Young Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
Molecular and Cellular Biology, 2025.5.25
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Decoding Health: Exploring Essential Biomarkers Linked to Metabolic Dysfunction-Associated Steatohepatitis and Type 2 Diabetes Mellitus
Sulagna Mukherjee, Seung-Soon Im
Biomedicines, 2025.2.4
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Enhancing Regulatory T cell function by mevalonate pathway inhibition prevents liver fibrosis
An-Na Bae, Hajin Lee, Huiseong Yang, Sulagna Mukherjee, Seung-Soon Im , Jae-Ho Lee, Jong Ho Park
Biochemical and biophysical Research communications, 2025.1.
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Fulvic acid inhibits the differentiation of 3T3-L1 adipocytes by activating the Ca2+/CaMKⅡ/AMPK pathway
Hyeon Yeong Ju, Seung-Eun Song, Su-Kyung Shin, Gil-Saeng Jeong, Ho-Chan Cho, Seung-Soon Im, Dae-Kyu Song
Biochemical and Biophysical Research Communications, 2025.1.
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Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis
Seungyeon Kim, Hyun-Ji Han, Hyunjin Rho, Subin Kang, Sulagna Mukherjee, Jiwoo Kim, Doyoun Kim, Hyuk Wan Ko, Sang Min Lim, Seung-Soon Im, Joon-Yong Chung, Jaewhan Song
Cellular and Molecular Life Sciences, 2025.1.31
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Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
Thuy Linh Lai , So Young Park , Giang Nguyen , Phuc Thi Minh Pham , Seon Mee Kang , Jeana Hong , Jae-Ho Lee , Seung-Soon Im , Dae-Hee Choi , Eun-Hee Cho
Endocrinology and Metabolism, 2024.11.5
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Impact of tibial transverse transport in tissue regeneration and wound healing with perspective on diabetic foot ulcers
Sulagna Mukherjee, Seung Soon Im
World Journal of Diabetes, 2024.5.15
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Regulation of betaine homocysteine methyltransferase by liver receptor homolog-1 in the methionine cycle
Hee-Kyung Han, Sulagna Mukherjee, Soo-Young Park, Jae-Ho Lee, Eun-Ho Lee,Suji Kim, Yun Han Lee, Dae-Kyu Song, Sooyeun Lee, Jae-Hoon Bae Seung-Soon IM
Molecular and Cellular Biology, 2024.5.28
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Loss of SREBP-1c ameliorates iron-induced liver fibrosis through decrease of lipocalin-2
Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F. Osborne, Dongryeol Ryu, Tae-Il Jeon & Seung-Soon Im
Experimental & Molecular Medicine, 2024.4.16
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Role of cytosolic and endoplasmic reticulum Ca2+ in pancreatic beta-cells: pros and cons
Seung-Eun Song, Su-Kyung Shin, Hyeon Yeong Ju, Seung-Soon Im, Dae-Kyu Song
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2024.2
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TAT38 and TAT38 mimics potently inhibit adipogenesis by repressing C/EBPα, PPARγ, Pi-PPARγ, and SREBP1 expression
Sun-Young Park, Dongyoon Shin, Young So Yoon, Sujin Park, Seung-Soon Im, Yeongshin Kim, Young-Soo Kim , CheolSoo Choi, Man-Wook Hur
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2024.6
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Lupenone attenuates thapsigargin-induced endoplasmic reticulum stress and apoptosis in pancreatic beta cells possibly through inhibition of protein tyrosine kinase 2 activity
Seung-Eun Song, Su-Kyung Shin, Yong-Woon Kim, Young Rok Do, Ae Kyoung Lim, Jae-Hoon Bae, Gil-Saeng Jeong, Seung-Soon Im, Dae-Kyu Song
Life Sciences, 2023.11.1
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Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium
Soo-Been Jeon, Hyebin Koh, A-Reum Han, Jieun Kim, Sunghun Lee, Jae-Ho Lee, Seung-Soon Im, Young-Sup Yoon, Jong-Hee Lee, Ji Yoon Lee
npj Regenerative Medicine, 2023.8.25
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Phloretin Ameliorates Succinate-Induced Liver Fibrosis by Regulating Hepatic Stellate Cells
Cong Thuc Le, Giang Nguyen, So Young Park, Hanh Nguyen Dong, Yun Kyung Cho, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho
Endocrinology and Metabolism, 2023.8.3
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Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Jung-Hwan Baek , Myung Sup Kim, Hye Ryeon Jung, Min-Seon Hwang, Chan-Ho Lee, Dai Hoon Han, Yong-Ho Lee , Eugene C Yi, Seung-Soon Im , Ilseon Hwang , Kyungeun Kim, Joon-Yong Chung, Kyung-Hee Chun
EXPERIMENTAL AND MOLECULAR MEDICINE, 2023.7.3
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High Sodium Intake, as Assessed by Urinary Sodium Excretion, Is Associated with Nonalcoholic Fatty Liver Disease or Sarcopenia
Eugene Han, Mi Kyung Kim, Seung-Soon Im, Hye Soon Kim, Taeg Kyu Kwon, Byoung Kuk Jang
Gut and Liver, 2023.5.15
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SCAP deficiency facilitates obesity and insulin resistance through shifiting adipose tissue macrophage polarization
Jea-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Teag Kyu Kwon, Byung-chul Oh,Kae Won Cho. Timothy F. Osborne, Tae-Il Jeon
Journal of Advanced Research, 2023.3
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Hepatocyte Kctd17 inhibition ameliorates glucose intolerance and hepatic steatosis caused by obesity-induced Chrebp stabilization
Ah-Reum Oh , Yelin Jeong , Junjie Yu , Dao Thi Minh Tam , Jin Ku Kang , Young Hoon Jung , Seung-Soon Im , Sang Bae Lee , Dongryeol Ryu, Utpal B Pajvani , KyeongJin Kim
Gastroenterology, 2023.3
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RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling
So-Young Park, Daekwan Seo, Eun-Hye Jeon, Jee Young Park, Byeong-Churl Jang, Jee In Kim, Seung-Soon Im, Jae-Ho Lee, Shin Kim,Chi Heum Cho,Yun-Han Lee
INTERNATIONAL JOURNAL OF ONCOLOGY, 2023.8
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Identification of pre-diabetic biomarkers in the progression of diabetes mellitus
Jae-Ho Lee, Do-Young Kim, Rubee Pantha, Eun-Ho Lee, Jae-Hoon Bae, Eugene Han, Dae-kyu Song, Taeqkyu Kwon and Seung-Soon Im
Biomedicines, 2022.12.30
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Function of gaseous hydrogen sulfide in liver fibrosis
Jae-Ho Lee, Seung-Soon Im
BMB report, 2022.10.31
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Non-alcoholic fatty liver disease and sarcopenia is associated with the risk of albuminuria independent of insulin resistance, and obesity
Eugene Han, Mi Kyung Kim, Seung-Soon Im, Byoung Kuk Jang, Hye Soon Kim
Journal Diabetes Complications, 2022.8.1
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Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells
Seung Un Seo, Seon Min Woo, Seung-Soon Im, Younghoon Jang, Eugene Han,Sang Hyun Kim,Hongchan Lee,Hyun-Shik Lee,Ju-Ock Nam,Edward Gabrielson,Kyoung-jin Min and Taeg Kyu Kwon
Cell death & disease, 2022.2.4
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Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo
Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-jin Min & Taeg Kyu Kwon
Oncogene, 2022.1.21
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SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
Thuy T.P. Nguyen, Do-Young Kim, Yu-Geon Lee, Young-Seung Lee, Xuan T. Truong, Jae-Ho Lee, Dae-Kyu Song,Taeg Kyu Kwon So-Hyun Park, Chang Hwa Jung, Changjong Moon, Timothy F. Osborne Seung-Soon Im,Tae-Il Jeon
Molecular Cell, 2021.9.16
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SREBP-1c Deficiency Affects Hippocampal Micromorphometry and Hippocampus-Dependent Memory Ability in Mice
Mary Jasmin Ang, Sueun Lee, Mai Wada, Poornima D E Weerasinghe-Mudiyanselage, Sung-Ho Kim, Taekyun Shin , Tae-Il Jeon, Seung-Soon Im, Changjong Moon
International Journal of Molecular Sciences, 2021.6
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Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism
Rubee Pantha, Jae-Ho Lee, Jae-Hoon Bae, Eun Hee Koh, Minsang Shin, Dae-Kyu Song & Seung-Soon Im
BMB report, 2021.9
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Impairment of ULK1 sulfhydration-mediated lipophagy by SREBF1/SREBP-1c in hepatic steatosis
Thuy T.P. Nguyen, Do-Young Kim, Seung-Soon Im & Tae-Il Jeon
Autophagy, 2021.12
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Withaferin A exerts an anti-obesity effect by increasing energy expenditure through thermogenic gene expression in high-fat diet-fed obese mice
Da-Hye Lee, So-Hyun Park, Eunyoung Lee, Hyo-Deok Seo, Jiyun Ahn, Young-Jin Jang , Tae-Youl Ha, Seung Soon Im, Chang Hwa Jung
Phytomedicine, 2020.12.30
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The cellular function of SCAP in metabolic signaling
Sun Hee Lee, Jae-Ho Lee & Seung-Soon Im
Experimental & Molecular Medicine, 2020.5.8
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Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
Lee JH, Go Y, Kim DY, Lee SH, Kim OH, Jeon YH, Kwon TK, Bae JH, Song DK, Rhyu IJ, Lee IK, Shong M, Oh BC, Petucci C, Park JW, Osborne TF, Im SS.
Experimental & Molecular Medicine, 2020.6
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SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress
Gung Lee , Hagoon Jang, Ye Young Kim, Sung Sik Choe, Jinuk Kong, Injae Hwang, Jeu Park, Seung-Soon Im, Jae Bum Kim
Diabetes, 2019.1
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Deficiency of sterol regulatory element-binding protein-1c induces schizophrenia-like behavior in mice
Sueun Lee, Sohi Kang, Mary Jasmin Ang, Juhwan Kim, Jong Choon Kim, Sung-Ho Kim, Tae-Il Jeon, Chaeyong Jung, Seung-Soon Im, Changjong Moon
Genes Brain and Behavior, 2019.4
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SREBP-1a stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4 directed mTORC1
Jae-Ho Lee, Peter Phelan, Minsang Shin, Byung-Chul Oh, Xianlin Han, Seung-Soon Im, and Timothy F. Osborne
Proceedings of the National Academy of Sciences of the United States of America, 2018.12.26
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PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting
Jae-Ho Lee, Hye Suk Kang, Hyeon Young Park, Young-Ah Moon, Yu Na Kang, Byung-Chul Oh, Dae-Kyu Song, Jae-Hoon Bae, Seung-Soon Im
Scientific Reports, 2017.8.30
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Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
Seung-Jae Kim , Ji-Young Cha, Hye Suk Kang, Jae-Ho Lee, Ji Yoon Lee, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
BMB report, 2016.5.1
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Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Hye Suk Kang, Ho-Chan Cho, Jae-Ho Lee, Goo Taeg Oh, Seung-Hoi Koo, Byung-Hyun Park, In-Kyu Lee, Hueng-Sik Choi, Dae-Kyu Song, Seung-Soon Im
Scientific Reports, 2016.3.24
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Regulation of IGFBP-2 expression during fasting
Hye Suk Kang, Mi-Young Kim, Seung-Jae Kim, Jae-Ho Lee, Yong-Deuk Kim, Young-Kyo Seo, Jae-Hoon Bae, Goo-Taeg Oh, Dae-Kyu Song, Yong-Ho Ahn, Seung-Soon Im
Biochemical Journal, 2015.4.17
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B-cell translocation gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model
Yong Deuk Kim, Sun-Gyun Kim, Seung-Lark Hwang, Hueng-Sik Choi, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
Diabetes, 2014.1
